Hierapolis, 1, an ancient city of Syria Cyrrhestica, now in ruins, situated between Antioch and Mesopotamia, 14 m. W. of the Euphrates; had considerable commercial importance, and was famous for its great temple of Astarte. 2, A city of ancient Phrygia, 5 m. N. of Laodicea; the birthplace of Epictetus, and where Paul founded a church; was celebrated for its hot springs.